Latest from the G2MC Working Groups

G2MC Working Groups were formed to focus on specific initiatives critical to advancing the G2MC mission while supporting the activities of developing G2MC Flagship Projects. Continue reading for the latest updates on working group activities, including takeaways from the 5th Global Genomic Medicine Virtual Conference Breakout Sessions. 

If you are interested in being a part of one of the G2MC Working Groups below, please submit your interest using the Join Our Community form.

Education Working Group

The Education Working Group is led by G2MC Steering Team members Bruce Korf and Richard Haspel, and G2MC Executive Team member Vajira Dissanayake. The mission of the Education Working Group is to assess and facilitate educational activities to prepare providers in implementation of genomic medicine in clinical practice. Specifically, the group aims to develop courses, case studies, assessment tools and other educational resources; collaborate with other educational groups and organizations to develop educational resources and expand outreach opportunities; develop programs that support the G2MC Flagship Projects; and engage and involve young investigators along the way. 

In April 2020, the Education Working Group launched the G2MC Education Needs Assessment Survey. The survey was sent to all G2MC members and to all participants in the virtual meeting. The overall goal of the survey is to use the information collected to determine the best ways to internationally implement educational programs in genetics and genomics for health care professionals, by understanding the existing resources and needs on a country-by-country basis. Additionally, the results will serve as a foundation for the Education Working Group in identifying opportunities, developing resources, and establishing projects moving forward. The survey may also be published, making it available for use by other institutions. 

During the May 6 G2MC International Virtual Conference Education Breakout Session, preliminary results from the education needs survey were shared with session attendees. From the session, it was determined that valuable data could also be obtained from conference participants who weren’t necessarily G2MC members, resulting in the survey being reopened and shared with all Virtual Conference registrants. The new data will be analyzed and results are expected to be shared during the next scheduled conference. Also during the breakout session, participants discussed elements of the postponed Genomic Medicine Immersion Course – an interactive, educational session for local clinicians that was planned to take place during the originally scheduled conference in Santiago. A wide interest was expressed by breakout session attendees to be involved in the planning and implementation of the course, and as a result, the Education Working Group will involve these participants in future planning meetings.

Moving forward, the Education Working Group will continue to evaluate survey data with the goal of determining areas in most need of genomic medicine education, training, and resources. There are also opportunities for collaboration with the G2MC Policy Working Group as well as the Rare Diseases Flagship Project.

Evidence Working Group

The Evidence Working Group is led by G2MC Steering Committee members Marc Abramowicz and Fahd Al-Mulla. The group aims to monitor evidence of clinical utility of genomic medicine and to promote awareness about current evidence available to support genomic medicine. The ultimate goal is to promote the implementation of genomic medicine worldwide, including in low and middle income countries.

To carry out its mission, the Evidence Working Group has begun assessing currently available evidence of the clinical utility of genomic medicine. Literature is widely available on monogenic disorders – those that can be detected through a single gene or chromosome variant such as Down Syndrome or Cystic Fibrosis – and clinical utility has been amply demonstrated in this area. However, evidence is scarce for polygenic predisposition – disorders such as Coronary Heart Disease, Multiple Sclerosis, diabetes, and depression, where there is no single major gene variant. Thus, the Evidence Working Group is focusing its efforts to develop better search methods for evidence related to the clinical utility of genomic medicine as related to polygenic predisposition and methods for actively monitoring and promoting new evidence as it becomes available. 

During the May 6 G2MC International Conference Virtual Breakout Sessions, the Evidence Working Group convened with interested conference attendees to begin establishing a list of multigenic/multifactorial diseases for which the group will aim to monitor evidence and which will serve as seeding points to elaborate semi-automated literature searches for evidence of clinical utility of genomic medicine. The group also searched existing literature using specified keywords to determine which searches returned studies specific to the clinical utility of genomic medicine in the case of a multigenic/multifactorial disorders. 

By fall 2020, The Evidence Working Group plans to have a snapshot of the current evidence of the clinical utility of genomic medicine in polygenic disorders ready for publication. The group is also in the process of partnering with CSIRO to develop a semi-automated search mechanism which will use a specific algorithm to allow for better refined searches in the areas deemed significant by the Working Group. This approach will allow the group to actively monitor emerging evidence from the literature and clinical trials and provide regular updates to G2MC and other partner organizations. The development of the search tool is expected to be completed by 2022.

Policy Working Group

The G2MC Policy Working Group, led by G2MC Co-Chair Catalina Lopez-Correa and G2MC members Sue Hill and Laura Rodriguez, seeks to analyze global policy issues surrounding the implementation of genomic tools and knowledge into health care delivery. As the field of genomic medicine continues to rapidly evolve, emphasis is being placed on collecting genetic and biological information and sharing it broadly, leading to integrated research and better methods for diagnosing and treating health care conditions. However, policy surrounding genomic data collection and sharing methods is lacking, particularly in low and middle income countries (LMICs). Furthermore, unethical and inequitable use and sharing of data can, and has, resulted in countries and institutions restricting the sharing of data outside of their institution or country’s borders, limiting the potential benefits this data could provide to research and health care.  

To address these concerns, the G2MC Policy Working Group has merged efforts with  Australian Genomics, The University of Queensland Australia, and Queensland Genomics to perform a landscape analysis to determine how countries are implementing policies in large-scale genomic health projects across the globe. The result was an online catalogue that currently maps 64 initiatives from over 35 locations, providing information on policies and strategies, implementation frameworks, demonstration projects, and population-scale studies, in a repository that can be widely accessed, shared, and contributed to.

Additionally, Elissa Prichep, G2MC member and Precision Medicine Lead with the World Economic Forum, is leading the Leapfrogging with Precision Medicine workstream, and has engaged the G2MC Policy Working Group on the effort. Key outputs of the workstream are 1) a whitepaper with a high level, forward-looking, scalable policy framework and exploration of six ethical tensions; and 2) a companion guide presenting case studies and key questions on each ethical tension. These documents will be published in summer 2020.

During the May 6 G2MC International Conference Virtual Breakout Sessions, the Policy Working Group convened with session attendees to share the work being done by the group to gather feedback and to discuss potential opportunities for collaboration. Session participants also discussed existing and needed genomic medicine policies specific to their countries or institutions. Many attendees expressed an interest in collaborating with the Working Group and in particular assisting with the continuation of the landscape analysis.

Moving forward, the Policy Working Group will continue to expand upon the landscape analysis, explore potential collaborations and initiatives for growing the online catalogue of global genomic medicine initiatives, begin developing a roadmap for implementation of genomic medicine which will outline policy issues for consideration, and continue to identify opportunities for supporting the G2MC Flagship Projects.

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A Pardo VRosaChile
AbaanOganUnited States of America
AbadingoMichPhilippines
AbdelhakamDinaEgypt
AbdufulzomorodaIsrael
AbramowiczMarcSwitzerland
AdduculRufusPhilippines
AirikkalaElisaFinland
AkkenaRajeshIndia
Al-MullaFahdKuwait
AlabanAvivPhilippines
AlawarOmaymaUnited States of America
Alejandra Chavez SantoscoyR.Mexico
AliBassamUnited Arab Emirates
AliSuadMalaysia
AlvaradoVeraGuatemala
AlvarezCarolinaChile
Aly SangareMoussaMali
Andres Maureira CaviedesIgnacioChile
Ann AbacanMaryPhilippines
AnuradhaRajithaUnited States of America
AraosRafaelChile
AravenaTeresaChile
ArmisenRicardoChile
Ávila JaqueDianaChile
BabaiArwaUnited Kingdom
BabuMohanFinland
BaezPabloChile
BahcallOrliUnited States of America
Barlow-StewartKrisAustralia
barraza. ChileximenaChile
BelcherAndreaAustralia
BelcherAndreaAustralia
BertierGabrielleUnited States of America
BezuidenhoutHeidreSwitzerland
BlondelCarlosChile
Bon MacedaEbnerPhilippines
BrownCarlUnited States of America
BrugnolloAntonioBrazil
BryantNicUnited States of America
Buleje SonoJose LuisPeru
BustamanteEvaChile
CalaloCheryllPhilippines
CalzoneKathyUnited States of America
Cárdenas MuñozMatías Franklin Darío AlejandroChile
Carlos RubilarJuanChile
CarmonaPinkyPhilippines
CarrascoJavieraChile
CarvalloPilarChile
CastilloSilviaChile
CastilloValentinaChile
Cecilia PoliMariaChile
CerecedaKarinaChile
CherelStanBrazil
ChinonyeMaduagwunaNigeria
ChuYoyoHong Kong, China
CofréGlendaChile
CongXiaomeiUnited States of America
Coronado CavazosAydeéMexico
CortésBernalCosta Rica
CourtneyRobUnited States of America
CremonaLauraUnited States of America
DajoyagKevinaPhilippines
Danasabe JobbiYusufNigeria
DaniasKonstantinosGreece
Dawn MoralesKristinePhilippines
DíazCatherineChile
DickeySusanUnited States of America
DinatorJavieraChile
DissanayakeVajiraSri Lanka
Dominguez ValentinMevNorway
DowneyReneeUnited States of America
DunneEvanUnited States of America
Duran MojicaAnyeloChile
DwyerAndrewUnited States of America
E. López ParraJosefaSpain
EastKellyUnited States of America
Eduardo Hodar QuirogaChristianChile
El KamahGhadaEgypt
EncinaGonzaloChile
EricesAlejandroChile
Erika OrtezaMaryUnited States of America
EspinosayolandaChile
EsquivelBernardCanada
FadistaJoaoDenmark
FakhroKhalidQatar
FanarasVasileiosGreece
FanerMonettePhilippines
FasayeGraceUnited States of America
FebboPhilUnited States of America
FelicianoJazminePhilippines
FernandezMarioChile
FerreccioCatterinaChile
FieggenKarenSouth Africa
FindleyLaurieUnited States of America
FlorenciaMariaChile
Flores BjurströmCarmenSweden
FourniesHernanChile
From Sri LankaKamalathasanSri Lanka
FuentesIgnaciaChile
FuentesNoeliaArgentina
GahlWilliamUnited States of America
Garcia-BlojBenjaminChile
Garcia-HuidobroJenaroChile
Garrett-MeadNancyUnited States of America
GeyskensLilianeBelgium
GinsburgGeoffUnited States of America
GolfoGelliePhilippines
Gonzaga-JaureguiClaudiaUnited States of America
GonzalezEvelinChile
GonzálezIsabelChile
GoodhandPeterCanada
GriffinKatieAustralia
GronichNaomiIsrael
GuerraMarielaGuatemala
GutierrezMercedesMexico
GuzzardoPalomaUnited States of America
Guzzardo (US)PalomaUnited States of America
HammarAnne-MarjaFinland
HaspekRichUnited States of America
HernandezCarlosChile
HettiarachchiDineshaniSri Lanka
HobbsErnieUnited States of America
HowingtonLynnetteUnited States of America
HubbardTimUnited Kingdom
HungMing WaiHong Kong
HusermanJonathanChile
IglesiasDianaCanada
ImhofSaraUnited States of America
J. MorelliMarcoItaly
Jaldin CrespoLimbergChile
JenningsBarbaraUnited Kingdom
Jenny Marcelain CubillosKatherineChile
Jesús ZavalaMaríaChile
José CardonaJuanGuatemala
KachambwaPaidamoyoSouth Africa
KariofylliskaramperisGreece
KatsilaTheodoraGreece
KechagiaKonstantinaGreece
KennelHannahUnited States of America
KennyEimearUnited States of America
KesserwanChimeneUnited States of America
KhantAyekyawtMyanmar
KleinAndresChile
KocerAlissaUnited States of America
KolambageYasasSri Lanka
KorfBruceUnited States of America
KoslowAlanUnited States of America
KoufakiMargiannaGreece
KraiserTatianaChile
KumuthiniJuditSouth Africa
kunsokMalaysia
KutsunugiSaekoJapan
KyriakopoulouChristinaBelgium
LaaksonenMariFinland
LagosMarcelaChile
LandsmannPatriciaUnited States of America
LarrandaburuMarielaUruguay
LarrandaburuMarielaUruguay
Lay-SonGuillermoChile
LebensohnAlexandraUnited States of America
LeeJulianaMalaysia
LiDongUnited States of America
LiRonglingUnited States of America
LimLee-LingHong Kong, China
ListyasariNurinIndonesia
LiuYiUnited States of America
LizamaDomingoChile
LLamos PanequeArianneEcuador
LopezCatalinaColombia
LópezSergioChile
Lopez StarBethaniaMexico
Madrid CastilloAngelaPeru
Mae AvilaChristinePhilippines
Magbanua-CalaloChePhilippines
MaharjanKrishnaNepal
MaigaAl Hassan dit BaneyeMali
MakedonskaJanaBulgaria
MakridakisNickUnited States of America
MalopeMaleboSouth Africa
ManolioTeriUnited States of America
Maracaja CoutinhoViniciusBrazil
Marcelo Esquivel RomeroGustavoMexico
MargaritSoniaChile
Maria BuzalehAnaArgentina
Maria Martin ChileLuzChile
MarínMartaSpain
MartinFernandaChile
MartinRaineUnited States of America
MartinelliVivianeBrazil
MartínezMatíasChile
MatthijsGertBelgium
MaureiraIgnacioChile
Mawuli AdadeySamuelSouth Africa
MelitoVivianaArgentina
MelladoCeciliaChile
MeloCamilaChile
MendesGuilUnited States of America
MendezRodrigoArgentina
MerchantArshiyaUnited Kingdom
MerencillaRoxannePhilippines
MessersmithDonnaUnited States of America
MetspaluAndresEstonia
milleredwardUnited Kingdom
MishraRupeshNepal
MitropoulouChristinaGreece
MKThongUnited States of America
MogakaJohnBotswana
MooreHilaryUnited States of America
MulderNickySouth Africa
MunizTatianeBrazil
naparstekyaakovIsrael
NdadzaArinaoSouth Africa
NisselleAmyAustralia
NoordeenNafeesaSri Lanka
ObispoDaisyPeru
OchoaAnne SharmainePhilippines
OlguinValeriaChile
OlivaresGonzaloChile
Olugbemiro NafiuMikhailUnited States of America
OluwoleFemiSouth Africa
OnebunneEzinneNigeria
OngWinnieMalaysia
OrellanaVivianaChile
OrtegaVictoriaChile
OsorioClaudiaGuatemala
Pablo AlcayagaJuanChile
PadeniyaPadmapaniSri Lanka
PagnottaPriscilaArgentina
PareraVictoriaArgentina
PathiranaSajeewaniSri Lanka
Pati BhandariKailashIndia
Patricio MirandaJoseChile
Patricio Miranda - ChileJoseChile
PatrinosGeorgeGreece
PenangGaik SiewMalaysia
PereiraLygiaBrazil
PérezEduardoUnited States of America
PérezElisaChile
PilankarAsawariGermany
PollinToniUnited States of America
PopovicMilanBelgium
PosadaMarioUnited States of America
PrichepElissaUnited States of America
PriyawanshaThusharaSri Lanka
Puthen VeettilJitheshQatar
QuezadaMauricioChile
Quispe BravoBernardo EstebanPeru
RacomaMJPhilippines
Rakhra-BurrisTejinderUnited States of America
RamírezOrlandoChile
RasmussenSusanaChile
Rebolledo-JaramilloBorisChile
ReeseMartinUnited States of America
ReichardtJuergenAustralia
RellingMaryUnited States of America
RennertGadiIsrael
renniemelissaUnited States of America
RepettoGabrielaChile
RicherEtienneCanada
RivadaviaFernandoUnited States of America
RivasChrisEcuador
RivasSolangeChile
RobertsBenUnited States of America
RodriguezEstherSpain
RodriguezLauraUnited States of America
RodríguezCeciliaChile
RojasMarceloChile
SadeghpourAzitaUnited States of America
SalasSantiagoUnited States of America
San MartinEstebanChile
SandersNekeaUnited States of America
SayPabloUnited States of America
SchäferCarolinaChile
SchullySheriUnited States of America
ScottMeganSouth Africa
Sebastian MartinezHugoChile
ShiaoPamUnited States of America
ShibliRanaIsrael
ShuldinerAlanUnited States of America
SifaquiSofiaChile
SimoesVagnerBrazil
SinclairAndrewAustralia
SirisenaNirmalaSri Lanka
SismanoglouDespoinaGreece
smolowitzJaniceUnited States of America
SolisErnestoChile
SoorianarayananTharisiniMalaysia
SoorianarayananTharisiniMalaysia
Spring-PearsonCynthiaUnited States of America
SubasingheVindyaSri Lanka
SwaminathanSoumyaSwitzerland
ThundersMichelleNew Zealand
TiongSyMalaysia
Titus NgenoG.United States of America
TokutomiTomoharuJapan
ToledoKarenChile
ToroJessicaChile
ToweryMeredithUnited States of America
Tri Nugroho SupranotoYehudaIndonesia
TumanengRozelPhilippines
TumulakMa-AmPhilippines
TurraFelipeUnited States of America
Twumasi AboagyeElvisGhana
VahtMariliisEstonia
ValezJenniferColombia
VarelaLauraArgentina
VerdugoRicardoChile
Victoria Layson-LisingNadinePhilippines
Vila PerezMarianaArgentina
VillalbaCristalBrazil
VillarroelDanielaChile
VillarroelFranzChile
VinascoEdnaGuatemala
VossJoachimUnited States of America
VrentzouMarinikyGreece
WallingJenniferUnited States of America
WanChenCanada
WasikKajaUnited States of America
WiafeSamuelGhana
Wood USAGrantUnited States of America
Xorse AmuzuEvansUnited States of America
YalcouyéAbdoulayeMali
Yee LingCheahMalaysia
YusufAminuNigeria
ZambranoAnaEcuador
ZamoraVanessaGuatemala
ZickBrittanyUnited States of America
ZuccoliJohannaArgentina
-AndreaPeru
-FernandaUnited States of America
-FernandaBrazil
-PhilUruguay
-rizqasulaiman-baradienSouth Africa
-WaseemUnited States of America