G2MC Flagship Projects Updates

G2MC Flagship Projects are formed to address implementation and pragmatic clinical trial design of evidence-based genomic medicine, with a focus on underserved settings.  Flagship Projects operate independently, but their efforts are supported by the G2MC Working Groups. Currently, three main projects are underway or in development.  Continue reading for the latest updates on these projects.

If you are interested in being a part of one of the G2MC Flagship Projects below, please submit your interest using the Join Our Community form.

Family Health History

The Family Health History (FHH) flagship project is led by G2MC Steering Committee members and Flagship Project Co-Chairs Grant Wood and Theodora Katsila. This project aims to advance global recognition and implementation of family health history data collection tools and risk assessment methods among practitioners and patients. 

Family health history – a record of the diseases and health conditions in a family – is an effective and inexpensive method by which healthcare providers can assess an individual’s overall health and risk factors for disease. However, a major effort is needed to obtain family health history data in a standardized format; find data storage solutions for easy wide-scale data input and sharing; develop risk assessment algorithms; and combine clinical, genomic, and environmental data to create new knowledge for patient care. By better understanding the needs in each individual country, the FHH project aims to promote the benefits of family health history for patient self-knowledge, family sharing, public screening, pre-screening for genetic testing in a clinical setting, and research.

During the May 6 G2MC International Conference Virtual Breakout Sessions, the FHH subgroup convened with interested conference attendees to discuss potential collaborations and share ideas and next steps for moving forward. Until the in-person conference in 2021, the work of the G2MC FHH subgroup will be to collect use cases to fully understand the needs of each location, identify funding and resources, build an infrastructure for data collection and sharing, and begin collecting data. Completion of these efforts will result in the availability of data to be used to inform testing, clinical decision support, and family-based care over an individual’s lifespan.

Rare Diseases: Applying Exome Sequencing in Low and Middle Income Countries

The Rare Disease flagship project is led by G2MC Executive Team member and Flagship Projects Co-Chair, Alan Shuldiner, and G2MC Executive Team member, Vajira Dissanayake. The overall objective of this project is to enable low and middle income countries (LMICs) around the world to implement genome and exome sequencing in children with rare, undiagnosed genetic disorders. Exome sequencing (ES) is the standard of care for the molecular diagnosis of children with rare undiagnosed genetic disorders and has had a profound impact on diagnosis, early treatment and outcomes of patients and their family members. Unfortunately, this valuable diagnostic tool is not readily available in many LMICs. 

This project aims to implement evidence-based clinical exome sequencing in children with rare undiagnosed genetic disorders in LMICs by establishing a network of clinics in hospitals in areas in South America, the Caribbean Islands, Africa, Asia, the Pacific Islands and other LMICs where genome and exome sequencing would be implemented as a routine service to patients when clinically indicated.

During the May 6 G2MC International Virtual Conference Breakout Sessions, the Rare Disease subgroup convened with interested conference participants to discuss moving the project forward through a proposed collaboration with Regeneron – a biotechnology company that already employs a successful exome sequencing model – and other potential partners including the University of Maryland (UMD), and the Undiagnosed Diseases Network. The goal is to implement a minimum of ten clinical settings in selected regions across the globe within the next 2-5 years that will implement genome and exome sequencing in children with rare, undiagnosed genetic disorders. This effort will include education and training of local clinicians, potentially through collaborations with the G2MC Education Working Group, and will also include the establishment of a central coordinating center that will oversee administrative functions and harmonize efforts. In the longer term, the project seeks to establish hundreds of sites to seamlessly employ genome and exome sequencing that will drastically improve healthcare for those with rare and undiagnosed conditions worldwide.

Pharmacogenetics Flagship Project: EU-Africa Grant Proposal

The Pharmacogenetics flagship project is led by G2MC Co-Chair and Flagship Projects Co-Chair, George Patrinos. As part of this project, a grant proposal was submitted in June 2020 that would bring best practices from Personalized Medicine implementation from more- to less resourced countries, specifically, from countries in the European Union (EU) to African countries. The grant was developed in response to a current EU funding call for a partnership between the European Commission (EC) and Africa to plan the implementation of genomic and precision medicine to advance the field in Africa.

Personalized medicine, also known as precision medicine, is the tailoring of medical treatment to the individual characteristics of each patient. Through novel pharmaceutical and biotechnology products and services, personalized healthcare is supporting new models of healthcare delivery with a wealth of new possibilities for patients and societies. Personalized medicine is of high priority in the European Commission research agenda, with significant funding devoted to these types of projects. With African populations being characterized by a large degree of genetic diversity, a large opportunity exists for utilizing genomics and other omics approaches to better understand the basis of inherited and infectious diseases in African population to improve human health. Furthermore, personalized medicine in Africa is gradually gaining momentum, attracting international interest as the governments of African countries are scaling up their investment in health systems. 

This project proposes a collaboration between the European Union and African countries that will establish transnational projects and allow for the implementation of innovations and research capacities in personalized medicine that don’t currently exist across much of Africa. Furthermore, through the involvement of researchers in African countries, continental initiatives on the African continent will also get stronger and contribute more to global efforts at implementing personalized medicine.

LastFirstCountry
A Pardo VRosaChile
AbaanOganUnited States of America
AbadingoMichPhilippines
AbdelhakamDinaEgypt
AbdufulzomorodaIsrael
AbramowiczMarcSwitzerland
AdduculRufusPhilippines
AirikkalaElisaFinland
AkkenaRajeshIndia
Al-MullaFahdKuwait
AlabanAvivPhilippines
AlawarOmaymaUnited States of America
Alejandra Chavez SantoscoyR.Mexico
AliBassamUnited Arab Emirates
AliSuadMalaysia
AlvaradoVeraGuatemala
AlvarezCarolinaChile
Aly SangareMoussaMali
Andres Maureira CaviedesIgnacioChile
Ann AbacanMaryPhilippines
AnuradhaRajithaUnited States of America
AraosRafaelChile
AravenaTeresaChile
ArmisenRicardoChile
Ávila JaqueDianaChile
BabaiArwaUnited Kingdom
BabuMohanFinland
BaezPabloChile
BahcallOrliUnited States of America
Barlow-StewartKrisAustralia
barraza. ChileximenaChile
BelcherAndreaAustralia
BelcherAndreaAustralia
BertierGabrielleUnited States of America
BezuidenhoutHeidreSwitzerland
BlondelCarlosChile
Bon MacedaEbnerPhilippines
BrownCarlUnited States of America
BrugnolloAntonioBrazil
BryantNicUnited States of America
Buleje SonoJose LuisPeru
BustamanteEvaChile
CalaloCheryllPhilippines
CalzoneKathyUnited States of America
Cárdenas MuñozMatías Franklin Darío AlejandroChile
Carlos RubilarJuanChile
CarmonaPinkyPhilippines
CarrascoJavieraChile
CarvalloPilarChile
CastilloSilviaChile
CastilloValentinaChile
Cecilia PoliMariaChile
CerecedaKarinaChile
CherelStanBrazil
ChinonyeMaduagwunaNigeria
ChuYoyoHong Kong, China
CofréGlendaChile
CongXiaomeiUnited States of America
Coronado CavazosAydeéMexico
CortésBernalCosta Rica
CourtneyRobUnited States of America
CremonaLauraUnited States of America
DajoyagKevinaPhilippines
Danasabe JobbiYusufNigeria
DaniasKonstantinosGreece
Dawn MoralesKristinePhilippines
DíazCatherineChile
DickeySusanUnited States of America
DinatorJavieraChile
DissanayakeVajiraSri Lanka
Dominguez ValentinMevNorway
DowneyReneeUnited States of America
DunneEvanUnited States of America
Duran MojicaAnyeloChile
DwyerAndrewUnited States of America
E. López ParraJosefaSpain
EastKellyUnited States of America
Eduardo Hodar QuirogaChristianChile
El KamahGhadaEgypt
EncinaGonzaloChile
EricesAlejandroChile
Erika OrtezaMaryUnited States of America
EspinosayolandaChile
EsquivelBernardCanada
FadistaJoaoDenmark
FakhroKhalidQatar
FanarasVasileiosGreece
FanerMonettePhilippines
FasayeGraceUnited States of America
FebboPhilUnited States of America
FelicianoJazminePhilippines
FernandezMarioChile
FerreccioCatterinaChile
FieggenKarenSouth Africa
FindleyLaurieUnited States of America
FlorenciaMariaChile
Flores BjurströmCarmenSweden
FourniesHernanChile
From Sri LankaKamalathasanSri Lanka
FuentesIgnaciaChile
FuentesNoeliaArgentina
GahlWilliamUnited States of America
Garcia-BlojBenjaminChile
Garcia-HuidobroJenaroChile
Garrett-MeadNancyUnited States of America
GeyskensLilianeBelgium
GinsburgGeoffUnited States of America
GolfoGelliePhilippines
Gonzaga-JaureguiClaudiaUnited States of America
GonzalezEvelinChile
GonzálezIsabelChile
GoodhandPeterCanada
GriffinKatieAustralia
GronichNaomiIsrael
GuerraMarielaGuatemala
GutierrezMercedesMexico
GuzzardoPalomaUnited States of America
Guzzardo (US)PalomaUnited States of America
HammarAnne-MarjaFinland
HaspekRichUnited States of America
HernandezCarlosChile
HettiarachchiDineshaniSri Lanka
HobbsErnieUnited States of America
HowingtonLynnetteUnited States of America
HubbardTimUnited Kingdom
HungMing WaiHong Kong
HusermanJonathanChile
IglesiasDianaCanada
ImhofSaraUnited States of America
J. MorelliMarcoItaly
Jaldin CrespoLimbergChile
JenningsBarbaraUnited Kingdom
Jenny Marcelain CubillosKatherineChile
Jesús ZavalaMaríaChile
José CardonaJuanGuatemala
KachambwaPaidamoyoSouth Africa
KariofylliskaramperisGreece
KatsilaTheodoraGreece
KechagiaKonstantinaGreece
KennelHannahUnited States of America
KennyEimearUnited States of America
KesserwanChimeneUnited States of America
KhantAyekyawtMyanmar
KleinAndresChile
KocerAlissaUnited States of America
KolambageYasasSri Lanka
KorfBruceUnited States of America
KoslowAlanUnited States of America
KoufakiMargiannaGreece
KraiserTatianaChile
KumuthiniJuditSouth Africa
kunsokMalaysia
KutsunugiSaekoJapan
KyriakopoulouChristinaBelgium
LaaksonenMariFinland
LagosMarcelaChile
LandsmannPatriciaUnited States of America
LarrandaburuMarielaUruguay
LarrandaburuMarielaUruguay
Lay-SonGuillermoChile
LebensohnAlexandraUnited States of America
LeeJulianaMalaysia
LiDongUnited States of America
LiRonglingUnited States of America
LimLee-LingHong Kong, China
ListyasariNurinIndonesia
LiuYiUnited States of America
LizamaDomingoChile
LLamos PanequeArianneEcuador
LopezCatalinaColombia
LópezSergioChile
Lopez StarBethaniaMexico
Madrid CastilloAngelaPeru
Mae AvilaChristinePhilippines
Magbanua-CalaloChePhilippines
MaharjanKrishnaNepal
MaigaAl Hassan dit BaneyeMali
MakedonskaJanaBulgaria
MakridakisNickUnited States of America
MalopeMaleboSouth Africa
ManolioTeriUnited States of America
Maracaja CoutinhoViniciusBrazil
Marcelo Esquivel RomeroGustavoMexico
MargaritSoniaChile
Maria BuzalehAnaArgentina
Maria Martin ChileLuzChile
MarínMartaSpain
MartinFernandaChile
MartinRaineUnited States of America
MartinelliVivianeBrazil
MartínezMatíasChile
MatthijsGertBelgium
MaureiraIgnacioChile
Mawuli AdadeySamuelSouth Africa
MelitoVivianaArgentina
MelladoCeciliaChile
MeloCamilaChile
MendesGuilUnited States of America
MendezRodrigoArgentina
MerchantArshiyaUnited Kingdom
MerencillaRoxannePhilippines
MessersmithDonnaUnited States of America
MetspaluAndresEstonia
milleredwardUnited Kingdom
MishraRupeshNepal
MitropoulouChristinaGreece
MKThongUnited States of America
MogakaJohnBotswana
MooreHilaryUnited States of America
MulderNickySouth Africa
MunizTatianeBrazil
naparstekyaakovIsrael
NdadzaArinaoSouth Africa
NisselleAmyAustralia
NoordeenNafeesaSri Lanka
ObispoDaisyPeru
OchoaAnne SharmainePhilippines
OlguinValeriaChile
OlivaresGonzaloChile
Olugbemiro NafiuMikhailUnited States of America
OluwoleFemiSouth Africa
OnebunneEzinneNigeria
OngWinnieMalaysia
OrellanaVivianaChile
OrtegaVictoriaChile
OsorioClaudiaGuatemala
Pablo AlcayagaJuanChile
PadeniyaPadmapaniSri Lanka
PagnottaPriscilaArgentina
PareraVictoriaArgentina
PathiranaSajeewaniSri Lanka
Pati BhandariKailashIndia
Patricio MirandaJoseChile
Patricio Miranda - ChileJoseChile
PatrinosGeorgeGreece
PenangGaik SiewMalaysia
PereiraLygiaBrazil
PérezEduardoUnited States of America
PérezElisaChile
PilankarAsawariGermany
PollinToniUnited States of America
PopovicMilanBelgium
PosadaMarioUnited States of America
PrichepElissaUnited States of America
PriyawanshaThusharaSri Lanka
Puthen VeettilJitheshQatar
QuezadaMauricioChile
Quispe BravoBernardo EstebanPeru
RacomaMJPhilippines
Rakhra-BurrisTejinderUnited States of America
RamírezOrlandoChile
RasmussenSusanaChile
Rebolledo-JaramilloBorisChile
ReeseMartinUnited States of America
ReichardtJuergenAustralia
RellingMaryUnited States of America
RennertGadiIsrael
renniemelissaUnited States of America
RepettoGabrielaChile
RicherEtienneCanada
RivadaviaFernandoUnited States of America
RivasChrisEcuador
RivasSolangeChile
RobertsBenUnited States of America
RodriguezEstherSpain
RodriguezLauraUnited States of America
RodríguezCeciliaChile
RojasMarceloChile
SadeghpourAzitaUnited States of America
SalasSantiagoUnited States of America
San MartinEstebanChile
SandersNekeaUnited States of America
SayPabloUnited States of America
SchäferCarolinaChile
SchullySheriUnited States of America
ScottMeganSouth Africa
Sebastian MartinezHugoChile
ShiaoPamUnited States of America
ShibliRanaIsrael
ShuldinerAlanUnited States of America
SifaquiSofiaChile
SimoesVagnerBrazil
SinclairAndrewAustralia
SirisenaNirmalaSri Lanka
SismanoglouDespoinaGreece
smolowitzJaniceUnited States of America
SolisErnestoChile
SoorianarayananTharisiniMalaysia
SoorianarayananTharisiniMalaysia
Spring-PearsonCynthiaUnited States of America
SubasingheVindyaSri Lanka
SwaminathanSoumyaSwitzerland
ThundersMichelleNew Zealand
TiongSyMalaysia
Titus NgenoG.United States of America
TokutomiTomoharuJapan
ToledoKarenChile
ToroJessicaChile
ToweryMeredithUnited States of America
Tri Nugroho SupranotoYehudaIndonesia
TumanengRozelPhilippines
TumulakMa-AmPhilippines
TurraFelipeUnited States of America
Twumasi AboagyeElvisGhana
VahtMariliisEstonia
ValezJenniferColombia
VarelaLauraArgentina
VerdugoRicardoChile
Victoria Layson-LisingNadinePhilippines
Vila PerezMarianaArgentina
VillalbaCristalBrazil
VillarroelDanielaChile
VillarroelFranzChile
VinascoEdnaGuatemala
VossJoachimUnited States of America
VrentzouMarinikyGreece
WallingJenniferUnited States of America
WanChenCanada
WasikKajaUnited States of America
WiafeSamuelGhana
Wood USAGrantUnited States of America
Xorse AmuzuEvansUnited States of America
YalcouyéAbdoulayeMali
Yee LingCheahMalaysia
YusufAminuNigeria
ZambranoAnaEcuador
ZamoraVanessaGuatemala
ZickBrittanyUnited States of America
ZuccoliJohannaArgentina
-AndreaPeru
-FernandaUnited States of America
-FernandaBrazil
-PhilUruguay
-rizqasulaiman-baradienSouth Africa
-WaseemUnited States of America