• Pharmacogenomics:
    • Develop data repositories of PGx variants in diverse populations around the world
    • Develop a strategy to engage PIs and young investigators from low and middle income countries in PGx research and clinical implementation
  • Rare Disease Diagnosis using Exome Sequencing:
    • Implement exome sequencing in children with rare and undiagnosed disease for diagnosis and genome-informed patient care
    • Establish a global network for LMICs in this area
    • Train local clinicians and providers and evaluate outcomes
    • Develop a resource to facilitate rare disease diagnosis using next generation sequencing
  • Disease Risk Assessment:
    • Cancer
      • Collaborate with the World Economic Forum in Rwanda on breast cancer
      • Conduct family-based study on colon cancer screening coupled with whole genome sequencing in individuals to provide a framework for genomic implementation in South Africa and the Middle East
    • Family History
      • Deploy family health history for identification of individuals, families and populations at risk for common chronic diseases